Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

What is the prospect of indoleamine 2,3-dioxygenase 1 inhibition in cancer? Extrapolation from the past

8 Feb 2021

Abstract excerpt

Indoleamine 2,3-dioxygenase 1 (IDO1), a monomeric heme-containing enzyme, catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan metabolism, which plays an important role in immunity and neuronal function. Its implication in different pathophysiologic processes including cancer and neurodegenerative diseases has inspired the development of IDO1 inhibitors in the past decades. However,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biochemical Acid Research Studies
Share to Diet and metabolism studies
Share to Tryptophan and brain disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33557876
DOI: 10.1186/s13046-021-01847-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

What is the prospect of indoleamine 2,3-dioxygenase 1 inhibition in cancer? Extrapolation from the pastPMID 33557876Read ↗

The Kynurenine Pathway and Cancer: Why Keep It Simple When You Can Make It ComplicatedSemantic proximity Read ↗

The Targeting of Indoleamine 2,3 Dioxygenase ‐Mediated Immune Escape in CancerSemantic proximity Read ↗

Highlights at the gate of tryptophan catabolism: a review on the mechanisms of activation and regulation of indoleamine 2,3-dioxygenase (IDO), a novel target in cancer diseaseSemantic proximity Read ↗

Current Challenges for IDO2 as Target in Cancer ImmunotherapySemantic proximity Read ↗

Indoleamine 2,3-Dioxygenase 2 (IDO2): The Protein That Lived TwiceSemantic proximity Read ↗

Targeting the kynurenine pathway: another therapeutic opportunity in the metabolic crosstalk between cancer and immune cellsSemantic proximity Read ↗

Role of indoleamine 2,3-dioxygenase in health and diseaseSemantic proximity Read ↗

The indoleamine 2,3 dioxygenase pathway drives intratumoral B cell maintenanceSemantic proximity Read ↗

Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and diseaseSemantic proximity Read ↗

Targeting the kynurenine pathway in gliomas: Insights into pathogenesis, therapeutic targets, and clinical advancesSemantic proximity Read ↗

Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC)Semantic proximity Read ↗

Discovery and evaluation of inhibitors to the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1): Probing the active site-inhibitor interactions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.