Article
A novel fission-independent role of dynamin-related protein 1 in cardiac mitochondrial respiration.
Cardiovascular research - 1 Feb 2017
Zhang Huiliang, Wang Pei, Bisetto Sara, Yoon Yisang, Chen Quan, Sheu Shey-Shing, Wang Wang
Abstract excerpt
AIMS: Mitochondria in adult cardiomyocytes exhibit static morphology and infrequent dynamic changes, despite the high abundance of fission and fusion regulatory proteins in the heart. Previous reports have indicated that fusion proteins may bear functions beyond morphology regulation. Here, we investigated the role of fission protein, dynamin-related protein 1 (DRP1), on mitochondrial respiration regulation in...
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