Article
Hexokinase 1 forms rings that regulate mitochondrial fission during energy stress.
Molecular cell - 25 Jul 2024
Pilic Johannes, Gottschalk Benjamin, Bourgeois Benjamin, Habisch Hansjörg, Koshenov Zhanat, Oflaz Furkan E, Erdogan Yusuf C, Miri Seyed M, Yiğit Esra N, Aydın Mehmet Ş, Öztürk Gürkan, Eroglu Emrah, Shoshan-Barmatz Varda, Madl Tobias, Graier Wolfgang F, Malli Roland
Abstract excerpt
Metabolic enzymes can adapt during energy stress, but the consequences of these adaptations remain understudied. Here, we discovered that hexokinase 1 (HK1), a key glycolytic enzyme, forms rings around mitochondria during energy stress. These HK1-rings constrict mitochondria at contact sites with the endoplasmic reticulum (ER) and mitochondrial dynamics protein (MiD51). HK1-rings prevent mitochondrial fission by...
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