Article
Genetic Polymorphism of Drug-Metabolizing Enzymes CYP2C9 and CYP2C19 in Moroccan Population.
Genetic testing and molecular biomarkers - 1 May 2017
Afilal Driss, Basselam Mohamed Amine, Brakez Zahra, Chouham Said, Brehm António, Izaabel El Hassan
Abstract excerpt
BACKGROUND: The polymorphic cytochrome P450 isoenzymes CYP2C9 and CYP2C19 are involved in the biotransformation of a wide variety of clinical drugs. Their major alleles occur with varying frequencies among different populations worldwide and have been associated with a varied capacity to degrade important therapeutic agents. This gives rise to important individual and interethnic variability in drug metabolism...
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