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Article

Mechanism of Anti-Inflammatory Activity of TLR4-Interacting SPA4 Peptide.

ImmunoHorizons - 24 Aug 2021

Awasthi Shanjana, Kumar Gaurav, Ramani Vijay, Awasthi Vibhudutta, Rodgers Karla K, Xie Jun, Beierle Jacob, Kyere-Davies Gertrude, Singh Bhupinder, Rahman Negar, Chowdhury Asif Alam, Chataut Neha

Abstract excerpt

The TLR4-interacting SPA4 peptide suppresses inflammation. We assessed the structural and physicochemical properties and binding of SPA4 peptide to TLR4-MD2. We also studied the changes at the whole transcriptome level, cell morphology, viability, secreted cytokines and chemokines, and cell influx in cell systems and mouse models challenged with LPS and treated with SPA4 peptide. Our results demonstrated that the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34429343
DOI: 10.4049/immunohorizons.2100067
PMCID: PMC8673433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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