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Article

Small Molecule Mimetics of α-Helical Domain of IRAK2 Attenuate the Proinflammatory Effects of IL-33 in Asthma-like Mouse Models.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2018

Li Jinghong, Saruta Kunio, Dumouchel Justin P, Magat Jenna M, Thomas Joanna L, Ajami Dariush, Rebek Mitra, Rebek Julius, Bigby Timothy D

Abstract excerpt

IL-33 and its receptor ST2 play important roles in airway inflammation and contribute to asthma onset and exacerbation. The IL-33/ST2 signaling pathway recruits adapter protein myeloid differentiation primary response 88 (MyD88) to transduce intracellular signaling. MyD88 forms a complex with IL-R-associated kinases (IRAKs), IRAK4 and IRAK2, called the Myddosome (MyD88-IRAK4-IRAK2). The myddosome subsequently...

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Share to Asthma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-1 Receptor-Associated Kinases

Share to Interleukin-33

Share to Myeloid Differentiation Factor 88

Share to NF-kappa B

Share to Protein Conformation, alpha-Helical

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Source

Open in PubMed Open full text

Identifiers

PMID: 29728508
DOI: 10.4049/jimmunol.1700693
PMCID: PMC5988972

Genes

IRAK2
IRAK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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