Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A TLR4-interacting SPA4 peptide inhibits LPS-induced lung inflammation.

Innate immunity - 1 Dec 2013

Ramani Vijay, Madhusoodhanan Rakhesh, Kosanke Stanley, Awasthi Shanjana

Abstract excerpt

The interaction between surfactant protein-A (SP-A) and TLR4 is important for host defense. We have recently identified an SPA4 peptide region from the interface of SP-A-TLR4 complex. Here, we studied the involvement of the SPA4 peptide region in SP-A-TLR4 interaction using a two-hybrid system, and biological effects of SPA4 peptide in cell systems and a mouse model. HEK293 cells were transfected with plasmid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dendritic Cells
Share to Lipopolysaccharides
Share to Pneumonia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Interaction Maps

Share to Pulmonary Surfactant-Associated Protein A

Share to Shock, Septic

Share to Toll-Like Receptor 4

Share to Transgenes

Source

Identifiers

PMID: 23475791
DOI: 10.1177/1753425912474851

Genes

TLR4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A TLR4-interacting SPA4 peptide inhibits LPS-induced lung inflammation.PMID 23475791Read ↗

Mechanism of Anti-Inflammatory Activity of TLR4-Interacting SPA4 Peptide.Semantic proximity Read ↗

Exosomal miR‑301a‑3p of airway epithelial cells regulates macrophage polarization and promotes lung injury via the GATA1 pathway in acute respiratory distress syndromeSemantic proximity Read ↗

sNASP mutation aggravates to the TLR4-mediated inflammation in SLE by TAK1 pathwaySemantic proximity Read ↗

Structural Features Essential to the Antimicrobial Functions of Human SPLUNC1Semantic proximity Read ↗

MicroRNA‑16 regulates lipopolysaccharide‑induced inflammatory factor expression by targeting TLR4 in normal human bronchial epithelial cellsSemantic proximity Read ↗

Surfactant protein a inhibits lipopolysaccharide-induced immune cell activation by preventing the interaction of lipopolysaccharide with lipopolysaccharide-binding protein.Semantic proximity Read ↗

Genome editing of PAR2 through targeted delivery of CRISPR-Cas9 system for alleviating acute lung inflammation via ERK/NLRP3/IL-1β and NO/iNOS signallingSemantic proximity Read ↗

Surfactant protein A activation of atypical protein kinase C zeta in IkappaB-alpha-dependent anti-inflammatory immune regulation.Semantic proximity Read ↗

Tlr4: central component of the sole mammalian LPS sensor.Semantic proximity Read ↗

Recognition of LPS by TLR4: Potential for Anti-Inflammatory TherapiesSemantic proximity Read ↗

On the significance of Surfactant Protein-A within the human lungsSemantic proximity Read ↗

Structural basis of the proinflammatory signaling complex mediated by TSLPSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.