The impact of spike N501Y mutation on neutralizing activity and RBD binding of SARS-CoV-2 convalescent serum.

doi:10.1016/j.ebiom.2021.103544

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Article

The impact of spike N501Y mutation on neutralizing activity and RBD binding of SARS-CoV-2 convalescent serum.

EBioMedicine - 1 Sept 2021

Lu Lu, Chu Allen Wing-Ho, Zhang Ricky Ruiqi, Chan Wan-Mui, Ip Jonathan Daniel, Tsoi Hoi-Wah, Chen Lin-Lei, Cai Jian-Piao, Lung David Christopher, Tam Anthony Raymond, Yau Yat-Sun, Kwan Mike Yat-Wah, To Wing-Kin, Tsang Owen Tak-Yin, Lee Larry Lap-Yip, Yi Haisu, Ip Tak-Chuen, Poon Rosana Wing-Shan, Siu Gilman Kit-Hang, Mok Bobo Wing-Yee, Cheng Vincent Chi-Chung, Chan Kwok Hung, Yuen Kwok-Yung, Hung Ivan Fan-Ngai, To Kelvin Kai-Wang

Abstract excerpt

BACKGROUND: Several SARS-CoV-2 lineages with spike receptor binding domain (RBD) N501Y mutation have spread globally. We evaluated the impact of N501Y on neutralizing activity of COVID-19 convalescent sera and on anti-RBD IgG assays. METHODS: The susceptibility to neutralization by COVID-19 patients' convalescent sera from Hong Kong were compared between two SARS-CoV-2 isolates (B117-1/B117-2) from the α variant...

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PMID: 34419925
DOI: 10.1016/j.ebiom.2021.103544
PMCID: PMC8374549

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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