Article

The E484K mutation in the SARS-CoV-2 spike protein reduces but does not abolish neutralizing activity of human convalescent and post-vaccination sera

2021-01-29

Abstract excerpt

One year in the coronavirus disease 2019 (COVID-19) pandemic, the first vaccines are being rolled out under emergency use authorizations. It is of great concern that newly emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can escape antibody-mediated protection induced by previous infection or vaccination through mutations in the spike protein. The glutamate (E) to Lysine (K) substi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f317cad2-31fb-56cd-be11-53ebf2d10638
DOI: 10.1101/2021.01.26.21250543

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The E484K mutation in the SARS-CoV-2 spike protein reduces but does not abolish neutralizing activity of human convalescent and post-vaccination seraDOI 10.1101/2021.01.26.21250543Read

Local emergence and decline of a SARS-CoV-2 variant with mutations L452R and N501Y in the spike proteinSemantic proximity Read

SARS-CoV-2 spike variants exhibit differential infectivity and neutralization resistance to convalescent or post-vaccination sera.Semantic proximity Read

SARS-CoV-2 Variant B.1.1.7 is Susceptible to Neutralizing Antibodies Elicited by Ancestral Spike VaccinesSemantic proximity Read

SARS-CoV-2 spike E156G/Δ157-158 mutations contribute to increased infectivity and immune escape.Semantic proximity Read

SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral spike vaccines.Semantic proximity Read

Previous Infection Combined with Vaccination Produces Neutralizing Antibodies With Potency Against SARS-CoV-2 VariantsSemantic proximity Read

SARS-CoV-2 variants, spike mutations and immune escape.Semantic proximity Read

Research progress in spike mutations of SARS-CoV-2 variants and vaccine development.Semantic proximity Read

Neutralization of SARS-CoV-2 variants by rVSV-ΔG-spike-elicited human seraSemantic proximity Read

Serum Neutralizing Activity against B.1.1.7, B.1.351, and P.1 SARS-CoV-2 Variants of Concern in Hospitalized COVID-19 Patients.Semantic proximity Read

Previous Infection Combined with Vaccination Produces Neutralizing Antibodies with Potency against SARS-CoV-2 Variants.Semantic proximity Read

Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies.Semantic proximity Read