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Article

Loss-of-function missense variant ofAKAP4induced male infertility through reduced interaction with QRICH2 during sperm flagella development

11 Aug 2021

Abstract excerpt

Sperm fibrous sheath (FS) is closely related to sperm maturation, capacitation and motility, and A-kinase anchor protein 4 (AKAP4) is the most abundant protein in sperm FS. Previous studies found incomplete sperm FSs and abnormal flagella in Akap4 knockout mice. Meanwhile, it was reported that the partial deletion in AKAP4 is highly relevant to the dysplasia of the FS in an infertile man, and so far, there is no...

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PMID: 34415320
DOI: 10.1093/hmg/ddab234

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Loss-of-function missense variant ofAKAP4induced male infertility through reduced interaction with QRICH2 during sperm flagella developmentPMID 34415320Read ↗

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