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Article

Bi-allelic mutation in Fsip1 impairs acrosome vesicle formation and attenuates flagellogenesis in mice.

Redox biology - 1 Jul 2021

Gamallat Yaser, Fang Xiang, Mai Hanran, Liu Xiaonan, Li Hong, Zhou Pei, Han Dingding, Zheng Shuxin, Liao Caihua, Yang Miaomiao, Li Yan, Zuo Liandong, Sun Ling, Hu Hao, Li Na

Abstract excerpt

Fibrous sheath interacting protein 1 (Fsip1) is a cytoskeletal structural protein of the sperm flagellar proteome. A few studies have reported that it plays a vital role in the tumorigenesis and cancer progression. However, little is known about the role of Fsip1 in spermatogenesis and mammalian sperm flagellogenesis. Fsip1 protein showed the highest expression in round spermatids, and was translocated from...

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Identifiers

PMID: 33901807
DOI: 10.1016/j.redox.2021.101969
PMCID: PMC8099781

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