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Article

Homozygous variants in AKAP3 induce asthenoteratozoospermia and male infertility.

Journal of medical genetics - 1 Feb 2023

Liu Chunyu, Shen Ying, Tang Shuyan, Wang Jiaxiong, Zhou Yiling, Tian Shixiong, Wu Huan, Cong Jiangshan, He Xiaojin, Jin Li, Cao Yunxia, Yang Yihong, Zhang Feng

Abstract excerpt

BACKGROUND: As a common type of asthenoteratozoospermia, multiple morphological abnormalities of the sperm flagella (MMAF) can cause male infertility. Previous studies have revealed genetic factors as a major cause of MMAF. The known MMAF-associated genes are involved in the mitochondrial sheath, outer dense fibre or axoneme of the sperm flagella. These findings indicate the genetic heterogeneity of MMAF. METHODS...

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Identifiers

PMID: 35228300
DOI: 10.1136/jmedgenet-2021-108271

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