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Novel Compound Heterozygous Mutation in FSIP2 Causes Multiple Morphological Abnormalities of the Sperm Flagella (MMAF) and Male Infertility.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Sept 2022

Hou Meiqi, Xi Qingsong, Zhu Lixia, Jia Weimin, Liu Zhenxing, Wang Cheng, Zhou Xiaopei, Zhang Dazhi, Xing Chenxi, Peng Xuejie, Luo Yalin, Jin Lei, Li Zhou, Zhang Xianqin

Abstract excerpt

Multiple morphological abnormalities of the sperm flagella (MMAF), characteristic with bent, short, coiled, absent, and abnormal caliber flagella, is an important basis of male infertility. Genetic factors account for a large proportion of patients with MMAF. The fibrous sheath interacting protein 2 (FSIP2) has a significant function in the spermatogenesis and flagellar motility. In our study, a novel compound...

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PMID: 35672654
DOI: 10.1007/s43032-022-00965-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Novel Compound Heterozygous Mutation in FSIP2 Causes Multiple Morphological Abnormalities of the Sperm Flagella (MMAF) and Male Infertility.PMID 35672654Read ↗

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