Article
Biallelic Mutations in CFAP43 and CFAP44 Cause Male Infertility with Multiple Morphological Abnormalities of the Sperm Flagella.
American journal of human genetics - 1 Jun 2017
Tang Shuyan, Wang Xiong, Li Weiyu, Yang Xiaoyu, Li Zheng, Liu Wangjie, Li Caihua, Zhu Zijue, Wang Lingxiang, Wang Jiaxiong, Zhang Ling, Sun Xiaoling, Zhi Erlei, Wang Hongyan, Li Hong, Jin Li, Luo Yang, Wang Jian, Yang Shenmin, Zhang Feng
Abstract excerpt
Sperm motility is vital to human reproduction. Malformations of sperm flagella can cause male infertility. Men with multiple morphological abnormalities of the flagella (MMAF) have abnormal spermatozoa with absent, short, coiled, bent, and/or irregular-caliber flagella, which impair sperm motility. The known human MMAF-associated genes, such as DNAH1, only account for fewer than 45% of affected individuals....
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