Article
Vitamin K antagonist anticoagulant usage is associated with increased incidence and progression of osteoarthritis.
Annals of the rheumatic diseases - 1 May 2021
Boer Cindy G, Szilagyi Ingrid, Nguyen N Long, Neogi Tuhina, Meulenbelt Ingrid, Ikram M Arfan, Uitterlinden André G, Bierma-Zeinstra Sita, Stricker Bruno H, van Meurs Joyce B
Abstract excerpt
OBJECTIVES: Vitamin K is hypothesised to play a role in osteoarthritis (OA) pathogenesis through effects on vitamin K-dependent bone and cartilage proteins, and therefore may represent a modifiable risk factor. A genetic variant in a vitamin K-dependent protein that is an essential inhibitor for cartilage calcification, matrix Gla protein (MGP), was associated with an increased risk for OA. Vitamin K antagonist...
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