Article
VKORC1 haplotypes are associated with arterial vascular diseases (stroke, coronary heart disease, and aortic dissection).
Circulation - 28 Mar 2006
Wang Yibo, Zhang Weili, Zhang Yuhui, Yang Yuejin, Sun Lizhong, Hu Shengshou, Chen Jilin, Zhang Channa, Zheng Yi, Zhen Yisong, Sun Kai, Fu Chunyan, Yang Tao, Wang Jianwei, Sun Jing, Wu Haiying, Glasgow Wayne C, Hui Rutai
Abstract excerpt
BACKGROUND: The haplotypes in the gene vitamin K epoxide reductase complex subunit 1 (VKORC1) have been found to affect warfarin dose response through effects on the formation of reduced-form vitamin K, a cofactor for gamma-carboxylation of vitamin K-dependent proteins, which is involved in the coagulation cascade and has a potential impact on atherosclerosis. We hypothesized that VKORC1-dependent effects on the...
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