Characterization of dynamic changes in Matrix Gla Protein (MGP) gene expression as function of genetic risk alleles, osteoarthritis relevant stimuli, and the vitamin K inhibitor warfarin.

doi:10.1016/j.joca.2021.05.001

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Characterization of dynamic changes in Matrix Gla Protein (MGP) gene expression as function of genetic risk alleles, osteoarthritis relevant stimuli, and the vitamin K inhibitor warfarin.

Osteoarthritis and cartilage - 1 Aug 2021

Houtman E, Coutinho de Almeida R, Tuerlings M, Suchiman H E D, Broekhuis D, Nelissen R G H H, Ramos Y F M, van Meurs J B J, Meulenbelt I

Abstract excerpt

OBJECTIVE: We here aimed to characterize changes of Matrix Gla Protein (MGP) expression in relation to its recently identified OA risk allele rs1800801-T in OA cartilage, subchondral bone and human ex vivo osteochondral explants subjected to OA related stimuli. Given that MGP function depends on vitamin K bioavailability, we studied the effect of frequently prescribed vitamin K antagonist warfarin. METHODS:...

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PMID: 33984465
DOI: 10.1016/j.joca.2021.05.001

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