Article
Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand.
Annals of the rheumatic diseases - 1 Dec 2017
den Hollander Wouter, Boer Cindy G, Hart Deborah J, Yau Michelle S, Ramos Yolande F M, Metrustry Sarah, Broer Linda, Deelen Joris, Cupples L Adrienne, Rivadeneira Fernando, Kloppenburg Margreet, Peters Marjolein, Spector Tim D, Hofman Albert, Slagboom P Eline, Nelissen Rob G H H, Uitterlinden André G, Felson David T, Valdes Ana M, Meulenbelt Ingrid, van Meurs Joyce J B
Abstract excerpt
OBJECTIVE: Osteoarthritis (OA) is the most common form of arthritis and the leading cause of disability in the elderly. Of all the joints, genetic predisposition is strongest for OA of the hand; however, only few genetic risk loci for hand OA have been identified. Our aim was to identify novel genes associated with hand OA and examine the underlying mechanism. METHODS: We performed a genome-wide association study...
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