Association of VKORC1-1639G>A polymorphism with susceptibility to ossification of the posterior longitudinal ligament of the spine: a Korean study.

doi:10.1007/s00701-013-1747-4

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Article

Association of VKORC1-1639G>A polymorphism with susceptibility to ossification of the posterior longitudinal ligament of the spine: a Korean study.

Acta neurochirurgica - 1 Oct 2013

Chin Dong-Kyu, Han In-Bo, Ropper Alexander E, Jeon Young-Joo, Kim Do-Hyung, Kim Young-Sung, Park Youngseok, Teng Yang D, Kim Nam-Keun, Kuh Sung-Uk

Abstract excerpt

BACKGROUND: Abnormalities of bone metabolism may be involved in the pathogenesis of ossification of the posterior longitudinal ligament (OPLL) of the spine. Besides its hemostatic effect, vitamin K epoxide reductase complex subunit 1 (VKORC1) plays a pivotal role in bone mineralization. The aim of this study is to investigate whether single nucleotide polymorphisms (SNPs) of the VKORC1 gene are associated with...

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PMID: 23732872
DOI: 10.1007/s00701-013-1747-4

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VKORC1

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