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Article

Association Between VKORC1 Gene Polymorphisms and Osteopenia and Osteoporosis: A Systematic Review and Meta-Analysis.

Medicina (Kaunas, Lithuania) - 15 Jan 2026

Vesa Ştefan Cristian, Ichim Vlad-Mihai, Iluț Silvina, Miglietta Stefano, Lupu Mihai, Coada Camelia Alexandra, Macarie Antonia Eugenia, Chiroban Ovidiu, Buzoianu Anca Dana, Sabin Octavia

Abstract excerpt

Background and Objectives: The vitamin K epoxide reductase complex subunit 1 (VKORC1) plays a central role in the vitamin K cycle, which is essential for γ-carboxylation of multiple bone-related proteins. Genetic variants in VKORC1 may influence bone mineral density (BMD) and osteoporosis risk. Materials and Methods: A systematic review and meta-analysis were conducted to evaluate the association between VKORC1...

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Share to Bone Density
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to VKORC1 gene

Share to Genetic Predisposition to Disease

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Share to Polymorphism, Genetic

Share to Polymorphism, Single Nucleotide

Share to Vitamin K Epoxide Reductases

Source

Open in PubMed Open full text

Identifiers

PMID: 41597466
DOI: 10.3390/medicina62010180
PMCID: PMC12843655

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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