Article
Concerted and differential actions of two enzymatic domains underlie Rad5 contributions to DNA damage tolerance.
Nucleic acids research - 11 Mar 2015
Choi Koyi, Batke Sabrina, Szakal Barnabas, Lowther Jonathan, Hao Fanfan, Sarangi Prabha, Branzei Dana, Ulrich Helle D, Zhao Xiaolan
Abstract excerpt
Many genome maintenance factors have multiple enzymatic activities. In most cases, how their distinct activities functionally relate with each other is unclear. Here we examined the conserved budding yeast Rad5 protein that has both ubiquitin ligase and DNA helicase activities. The Rad5 ubiquitin ligase activity mediates PCNA poly-ubiquitination and subsequently recombination-based DNA lesion tolerance....
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