Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SFPQ rescues F508del-CFTR expression and function in cystic fibrosis bronchial epithelial cells.

Scientific reports - 17 Aug 2021

Kumar Parameet, Soni Dharmendra Kumar, Sen Chaitali, Larsen Mads B, Mazan-Mamczarz Krystyna, Piao Yulan, De Supriyo, Gorospe Myriam, Frizzell Raymond A, Biswas Roopa

Abstract excerpt

Cystic fibrosis (CF) occurs as a result of mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which lead to misfolding, trafficking defects, and impaired function of the CFTR protein. Splicing factor proline/glutamine-rich (SFPQ) is a multifunctional nuclear RNA-binding protein (RBP) implicated in the regulation of gene expression pathways and intracellular trafficking. Here, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bronchi
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cystic Fibrosis

Share to Cystic Fibrosis Transmembrane Conductance Regulator

Share to Epithelial Cells

Share to Gene Expression Regulation

Share to Mutation

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 34404863
DOI: 10.1038/s41598-021-96141-w
PMCID: PMC8371023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SFPQ rescues F508del-CFTR expression and function in cystic fibrosis bronchial epithelial cells.PMID 34404863Read ↗

SFPQ Rescues F508del-CFTR Expression and Function in Cystic Fibrosis Bronchial Epithelial CellsSemantic proximity Read ↗

SFPQ regulates the accumulation of RNA foci and dipeptide repeat proteins from the expanded repeat mutation in C9orf72.Semantic proximity Read ↗

Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALSSemantic proximity Read ↗

A conserved role for SFPQ in repression of pathogenic cryptic last exonsSemantic proximity Read ↗

Transcriptomic profile of cystic fibrosis patients identifies type I interferon response and ribosomal stalk proteins as potential modifiers of disease severity.Semantic proximity Read ↗

Long Non-coding RNA BGas Regulates the Cystic Fibrosis Transmembrane Conductance RegulatorSemantic proximity Read ↗

A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exonsSemantic proximity Read ↗

SFPQ intron retention, reduced expression and aggregate formation in central nervous system tissue are pathological features of amyotrophic lateral sclerosisSemantic proximity Read ↗

Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates in primary neurons.Semantic proximity Read ↗

Splicing factor proline- and glutamine-rich (SFPQ) protein causes transcriptional repression of SNAIL to counteract TGF-β signalingSemantic proximity Read ↗

Correcting the F508del-CFTR variant by modulating eukaryotic translation initiation factor 3-mediated translation initiation.Semantic proximity Read ↗

Familial ALS-associated <i>SFPQ</i> variants promote the formation of SFPQ cytoplasmic aggregates that reduce surface AMPA receptor expression in primary neuronsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.