Article

SFPQ Rescues F508del-CFTR Expression and Function in Cystic Fibrosis Bronchial Epithelial Cells

2021-04-27

Abstract excerpt

Cystic Fibrosis (CF) occurs as a result of mutations in the cystic fibrosis transmembrane conductance regulator ( CFTR ) gene, which lead to misfolding, trafficking defects, and impaired function of the CFTR protein. Splicing factor proline/glutamine-rich (SFPQ) is a multifunctional nuclear RNA-binding protein (RBP) implicated in the regulation of gene expression pathways and intracellular trafficking. Here, we in...

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Literature Corpus work: bcf4f646-62db-5697-9c0e-3cf60fc7f481
DOI: 10.21203/rs.3.rs-429698/v1

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