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Article

Protein domain-based approaches for the identification and prioritization of therapeutically actionable cancer variants.

Biochimica et biophysica acta. Reviews on cancer - 1 Dec 2021

Grillo Elisabetta, Ravelli Cosetta, Corsini Michela, Zammataro Luca, Mitola Stefania

Abstract excerpt

The tremendous number of cancer variants that can be detected by NGS analyses has required the development of computational approaches to prioritize mutations on the basis of their biological and clinical significance. Standard strategies take a gene-centric approach to the problem, allowing exclusively the identification of highly frequent variants. On the contrary, protein domain (PD)-based approaches allow to...

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PMID: 34403770
DOI: 10.1016/j.bbcan.2021.188614

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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