Comorbidity genetic risk and pathways impact SARS-CoV-2 infection outcomes

Abstract excerpt

<title>Abstract</title> <p>Understanding the genetic risk and mechanisms through which SARS-CoV-2 infection outcomes and comorbidities interact to impact acute and long-term sequelae is essential if we are to reduce the ongoing health burdens of the COVID-19 pandemic. Here we use a de novo protein diffusion network analysis coupled with tissue-specific gene regulatory networks, to examine putative mechanisms for...

Topics

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• Aged
• COVID-19
• Exome Sequencing
• Genetic Predisposition to Disease
• Host-Pathogen Interactions
• Polymorphism, Single Nucleotide
• SARS-CoV-2
• Severity of Illness Index

Identifiers and source

Literature Corpus work

e2280cb2-f5db-5d64-a8d8-c1a05fd342ce

DOI

10.21203/rs.3.rs-1825793/v1