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Article

Clinical utility of clonal origin determination in managing recurrent hepatocellular carcinoma.

Expert review of gastroenterology & hepatology - 1 Oct 2021

Gupta Shubham, Khan Sikandar, Kawka Michal, Gujjuri Rohan, Chau Ian, Starling Naureen, Cunningham David, Jiao Long R, Gall Tamara

Abstract excerpt

INTRODUCTION: Recurrence is the driving factor for reduced long-term survival in patients following resected hepatocellular carcinoma (HCC). Extensive research efforts have been conducted to understand the molecular processes precipitating disease recurrence. Modern genomic techniques have identified two distinct mechanisms for recurrent HCC (RHCC): Intrahepatic metastasis (IM-HCC); and multicentric origin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 34402366
DOI: 10.1080/17474124.2021.1967144

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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