Article
Clonal evolution in long-term follow-up patients with hepatocellular carcinoma.
International journal of cancer - 1 Dec 2018
Chen Geng, Cai Zhixiong, Li Zhenli, Dong Xiuqing, Xu Haipo, Lin Jianling, Chen Lihong, Zhang Huqin, Liu Xiaolong, Liu Jingfeng
Abstract excerpt
To investigate tumor clonal evolution in hepatocellular carcinoma (HCC), we collected 31 tumor samples,16 peritumor samples and matched PBMCs from 11 long-term follow-up patients with HCC. Whole-exome sequencing was performed to obtain SNVs and CNVs for each sample. An average of 652.2 somatic mutations were identified in each patient and the mean percentage of nonubiquitous tumor mutations was 63.7% (range,...
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