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Genomic and Epigenomic Features of Primary and Recurrent Hepatocellular Carcinomas

24 Sept 2019

Abstract excerpt

Background & Aims Intratumor heterogeneity and divergent clonal lineages within and among primary and recurrent hepatocellular carcinomas (HCCs) produce challenges to patient management. We investigated genetic and epigenetic variations within liver tumors, among hepatic lesions, and between primary and relapsing tumors. Methods Tumor and matched nontumor liver specimens were collected from 113 patients who...

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PMID: 31560893
DOI: 10.1053/j.gastro.2019.09.005

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