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Article

BRAF Mutation Drives Early Multifocal Intrahepatic Recurrence after Curative Resection of Liver-Limited Colorectal Metastases.

Journal of the American College of Surgeons - 1 Apr 2026

Akabane Miho, Baldo Andrea, Kawashima Jun, Aucejo Federico, Popescu Irinel, Kitago Minoru, Poultsides George A, Ruzzenente Andrea, Endo Itaru, Pawlik Timothy M

Abstract excerpt

BACKGROUND: BRAF mutations occur in only 2% to 5% of patients undergoing hepatectomy for colorectal liver metastases (CRLM), and their mutation-specific recurrence patterns-especially in comparison with KRAS -remain poorly defined. STUDY DESIGN: An international, multi-institutional database was queried for adults who underwent curative-intent resection of liver-limited CRLM between 2000 and 2023 (N = 1,729)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

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Source

Identifiers

PMID: 41532624
DOI: 10.1097/XCS.0000000000001748

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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