Association between Locoregional Failure and NFE2L2/KEAP1/CUL3 Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer.

doi:10.1158/1078-0432.CCR-24-2334

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Article

Association between Locoregional Failure and NFE2L2/KEAP1/CUL3 Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2025

Guan Li, Torres-Saavedra Pedro A, Zhao Xiaobei, Major Michael B, Holmes Brittany J, Nguyen Ngan K, Kumaravelu Parasakthy, Hodge Tim, Diehn Maximilian, Zevallos Jose, Holsinger F Christopher, Emami Bahman, Jordan Richard C, Hayward Michele C, Sagar Stephen M, Morrison William, Schultz Christopher, Caudell Jimmy J, Jones Christopher U, Bratman Scott V, Galloway Thomas J, Ma Daniel J, Yom Sue S, Kudrimoti Mahesh, Kim Harold E, Harris Jonathan, Le Quynh-Thu, Hayes D Neil

Abstract excerpt

PURPOSE: NFE2L2/KEAP1/CUL3 mutations have been validated for radioresistance in cell-based assays and animal models. However, clinical validation of these biomarkers has been challenging because of multimodality treatment regimens. This study aims to investigate the association between NFE2L2/KEAP1/CUL3 mutations and patient outcomes, including local failure, locoregional failure, disease-free survival (DFS), and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39656603
DOI: 10.1158/1078-0432.CCR-24-2334
PMCID: PMC12045734

Genes

CUL3
KEAP1
NFE2L2

Provenance

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