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Article

New insight into the role of SMAD4 mutation/deficiency in the prognosis and therapeutic resistance of pancreatic ductal adenocarcinomas.

Biochimica et biophysica acta. Reviews on cancer - 1 Nov 2024

Yao Hongjuan, Luo Liaoxin, Li Rui, Zhao Yelin, Zhang Li, Pešić Milica, Cai Lin, Li Liang

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) patients have an unfavorable prognosis and disappointing treatment outcomes because of late diagnosis, high chemotherapy resistance, ineffective adjuvant chemotherapy, unavailable molecular targeted therapy, and profound immunosuppressive effects in the tumor microenvironment (TME). There are a variety of critical driver proteins, such as KRAS, TP53, PTEN and SMAD4,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39571764
DOI: 10.1016/j.bbcan.2024.189220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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