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Article

Mapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan.

Nature communications - 13 Aug 2021

Feng Likui, Gordon Matthew T, Liu Ying, Basso Kari B, Butcher Rebecca A

Abstract excerpt

Polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) hybrid systems typically use complex protein-protein interactions to facilitate direct transfer of intermediates between these multimodular megaenzymes. In the canal-associated neurons (CANs) of Caenorhabditis elegans, PKS-1 and NRPS-1 produce the nemamides, the only known hybrid polyketide-nonribosomal peptides biosynthesized by animals,...

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Identifiers

PMID: 34389721
DOI: 10.1038/s41467-021-24682-9
PMCID: PMC8363725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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