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Article

Lanthionine ketimine ethyl ester partially rescues neurodevelopmental defects in unc-33 (DPYSL2/CRMP2) mutants.

Journal of neuroscience research - 1 Sept 2013

Hubbard Caleb, Benda Erica, Hardin Tyler, Baxter Taylor, St John Elizabeth, O'Brien Sean, Hensley Kenneth, Holgado Andrea M

Abstract excerpt

Lanthionine ketimine (LK) is a natural sulfur amino acid metabolite with potent neurotrophic activity. Proteomics indicate that LK interacts with collapsin response mediator protein-2 (CRMP2/DPYSL2/UNC-33), a brain-enriched protein that was shown to regulate cytoskeletal remodeling, neuronal morphology, and synaptic function. To elucidate further the molecular interplay and biological action of LK and UNC-33, we...

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Source

Identifiers

PMID: 23825043
DOI: 10.1002/jnr.23239

Genes

DPYSL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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