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Article

Population diversity of three variants of the SLC47A2 gene (MATE2-K transporter) in Mexican Mestizos and Native Americans.

Molecular biology reports - 1 Sept 2021

Favela-Mendoza Alma Faviola, Fricke-Galindo Ingrid, Cuevas-Sánchez Wendy Fernanda, Aguilar-Velázquez José Alonso, Martínez-Cortés Gabriela, Rangel-Villalobos Héctor

Abstract excerpt

BACKGROUND: MATE2-K is an efflux transporter protein of organic cation expressed mainly in the kidney and encoded by the SLC47A2 gene. Different variants of this gene have shown an impact on the pharmacokinetics of various drugs, including metformin, which represents one of the most widely used drugs in treating type 2 diabetes. The SLC47A2 gene variants have been scarcely studied in Mexican populations,...

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PMID: 34383246
DOI: 10.1007/s11033-021-06628-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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