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Article

Unraveling a Ligand-Induced Twist of a Homodimeric Enzyme by Pulsed Electron-Electron Double Resonance.

Angewandte Chemie (International ed. in English) - 18 Oct 2021

Nguyen Dzung, Abdullin Dinar, Heubach Caspar A, Pfaffeneder Toni, Nguyen Andreas, Heine Andreas, Reuter Klaus, Diederich François, Schiemann Olav, Klebe Gerhard

Abstract excerpt

Mechanistic insights into protein-ligand interactions can yield chemical tools for modulating protein function and enable their use for therapeutic purposes. For the homodimeric enzyme tRNA-guanine transglycosylase (TGT), a putative virulence target of shigellosis, ligand binding has been shown by crystallography to transform the functional dimer geometry into an incompetent twisted one. However, crystallographic...

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Identifiers

PMID: 34387025
DOI: 10.1002/anie.202108179
PMCID: PMC8597004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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