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The Importance of Charge in Perturbing the Aromatic Glue Stabilizing the Protein-Protein Interface of Homodimeric tRNA-Guanine Transglycosylase.

ACS chemical biology - 20 Nov 2020

Nguyen Andreas, Nguyen Dzung, Phong Nguyen Tran Xuan, Sebastiani Maurice, Dörr Stefanie, Hernandez-Alba Oscar, Debaene François, Cianférani Sarah, Heine Andreas, Klebe Gerhard, Reuter Klaus

Abstract excerpt

Bacterial tRNA-guanine transglycosylase (Tgt) is involved in the biosynthesis of the modified tRNA nucleoside queuosine present in the anticodon wobble position of tRNAs specific for aspartate, asparagine, histidine, and tyrosine. Inactivation of the tgt gene leads to decreased pathogenicity of Shigella bacteria. Therefore, Tgt constitutes a putative target for Shigellosis drug therapy. Since it is only active as...

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PMID: 33166460
DOI: 10.1021/acschembio.0c00700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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