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Article

Substrate-dependent unfolding of the energy coupling motif of a membrane transport protein determined by double electron-electron resonance.

Biochemistry - 12 Sept 2006

Xu Qi, Ellena Jeffrey F, Kim Miyeon, Cafiso David S

Abstract excerpt

BtuB is a TonB-dependent transport protein that binds and carries vitamin B(12) across the outer membrane of Gram negative bacteria such as Escherichia coli. Previous work has demonstrated that the Ton box, a highly conserved segment near the N-terminus of the protein, undergoes an order-to-disorder transition upon the binding of substrate. Here, we incorporate pairs of nitroxide spin labels into membrane...

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Identifiers

PMID: 16953570
DOI: 10.1021/bi061051x
PMCID: PMC2515220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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