Article
Taking a molecular motor for a spin: helicase mechanism studied by spin labeling and PELDOR.
Nucleic acids research - 29 Jan 2016
Constantinescu-Aruxandei Diana, Petrovic-Stojanovska Biljana, Schiemann Olav, Naismith James H, White Malcolm F
Abstract excerpt
The complex molecular motions central to the functions of helicases have long attracted attention. Protein crystallography has provided transformative insights into these dynamic conformational changes, however important questions about the true nature of helicase configurations during the catalytic cycle remain. Using pulsed EPR (PELDOR or DEER) to measure interdomain distances in solution, we have examined two...
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