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Article

Adherence to Bürgi-Dunitz stereochemical principles requires significant structural rearrangements in Schiff-base formation: insights from transaldolase complexes.

Acta crystallographica. Section D, Biological crystallography - 1 Feb 2014

Light Samuel H, Minasov George, Duban Mark-Eugene, Anderson Wayne F

Abstract excerpt

The Bürgi-Dunitz angle (αBD) describes the trajectory of approach of a nucleophile to an electrophile. The adoption of a stereoelectronically favorable αBD can necessitate significant reactive-group repositioning over the course of bond formation. In the context of enzyme catalysis, interactions with the protein constrain substrate rotation, which could necessitate structural transformations during bond...

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Identifiers

PMID: 24531488
DOI: 10.1107/S1399004713030666
PMCID: PMC3940192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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