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Article

Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy.

Nature structural & molecular biology - 1 Aug 2009

Perez-Jimenez Raul, Li Jingyuan, Kosuri Pallav, Sanchez-Romero Inmaculada, Wiita Arun P, Rodriguez-Larrea David, Chueca Ana, Holmgren Arne, Miranda-Vizuete Antonio, Becker Katja, Cho Seung-Hyun, Beckwith Jon, Gelhaye Eric, Jacquot Jean P, Gaucher Eric A, Gaucher Eric, Sanchez-Ruiz Jose M, Berne Bruce J, Fernandez Julio M

Abstract excerpt

Thioredoxins (Trxs) are oxidoreductase enzymes, present in all organisms, that catalyze the reduction of disulfide bonds in proteins. By applying a calibrated force to a substrate disulfide, the chemical mechanisms of Trx catalysis can be examined in detail at the single-molecule level. Here we u...

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PMID: 19597482
DOI: 10.1038/nsmb.1627
PMCID: PMC2745927

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-19597482-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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