Article
Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses.
Nature communications - 12 Aug 2021
Chen Qian, Coto-Llerena Mairene, Suslov Aleksei, Teixeira Raphael Dias, Fofana Isabel, Nuciforo Sandro, Hofmann Maike, Thimme Robert, Hensel Nina, Lohmann Volker, Ng Charlotte K Y, Rosenberger George, Wieland Stefan, Heim Markus H
Abstract excerpt
Genetic variants of the interferon lambda (IFNL) gene locus are strongly associated with spontaneous and IFN treatment-induced clearance of hepatitis C virus (HCV) infections. Individuals with the ancestral IFNL4-dG allele are not able to clear HCV in the acute phase and have more than a 90% probability to develop chronic hepatitis C (CHC). Paradoxically, the IFNL4-dG allele encodes a fully functional IFNλ4...
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