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Histone deacetylase inhibition leads to regulatory histone mark alterations and impairs meiosis in oocytes

12 Aug 2021

Abstract excerpt

BACKGROUND: Panobinostat (PB), a histone deacetylase (HDAC) inhibitor drug, is clinically used in the treatment of cancers. We investigated the effects of PB on murine ovarian functions in embryos and adult animals. METHODS: C57BL/6J mice were treated with 5 mg/kg PB on alternate days from embryonic day (E) 6.5 to E15.5. We analysed the effects of PB on the ovaries by using immunofluorescence, gene expression...

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PMID: 34384478
DOI: 10.1186/s13072-021-00413-8

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