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Epigenetic status determines germ cell meiotic commitment in embryonic and postnatal mammalian gonads

15 Jan 2010

Abstract excerpt

The meiotic cell cycle is required for production of fertilization-competent gametes. Germ cell meiotic commitment requires expression of Stimulated by retinoic acid gene 8 (Stra8), which is transcriptionally activated by retinoic acid (RA). Meiotic suppression in embryonic male germ cells is believed to result from sex-specific differences in CYP26B1-catalyzed RA metabolism in the developing gonads. Here we show...

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PMID: 20009537
DOI: 10.4161/cc.9.2.10447

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