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Intracytoplasmic oxidative stress reverses epigenetic modifications in polycystic ovary syndrome

25 Apr 2017

Abstract excerpt

In polycystic ovary syndrome (PCOS), substantial genetic and environmental alterations, along with hyperandrogenism, affect the quality of oocytes and decrease ovulation rates. To determine the mechanisms underlying these alterations caused specifically by an increase in plasma androgens, the present study was performed in experimentally-induced PCOS mice. As the study model, female B6D2F1 mice were treated with...

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PMID: 28442024
DOI: 10.1071/rd16428

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