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Article

CPEB controls oocyte growth and follicle development in the mouse

18 Oct 2006

Abstract excerpt

CPEB is a sequence-specific RNA-binding protein that regulates polyadenylation-induced translation. In Cpeb knockout mice, meiotic progression is disrupted at pachytene due to inhibited translation of synaptonemal complex protein mRNAs. To assess the function of CPEB after pachytene, we used the zona pellucida 3 (Zp3) promoter to generate transgenic mice expressing siRNA that induce the destruction of Cpeb mRNA....

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PMID: 17050619
DOI: 10.1242/dev.02651

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