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Sirt6 depletion causes spindle defects and chromosome misalignment during meiosis of mouse oocyte

20 Oct 2015

Abstract excerpt

Sirt6, a member of the sirtuin family of NAD-dependent protein deacetylases, has been implicated in multiple biological processes. However, the roles of Sirt6 in meiosis have not been addressed. In the present study, by employing knockdown analysis in mouse oocytes, we evaluated the effects of Sirt6 on meiotic apparatus. We found that specific depletion of Sirt6 results in disruption of spindle morphology and...

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PMID: 26481302
DOI: 10.1038/srep15366

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