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Article

Invariant chain transmembrane domain trimerization: a step in MHC class II assembly.

Biochemistry - 25 Apr 2006

Dixon Ann M, Stanley Bradford J, Matthews Erin E, Dawson Jessica P, Engelman Donald M

Abstract excerpt

The transmembrane (TM) domain of the major histocompatibility complex (MHC) class II-associated invariant chain (Ii) has long been implicated in both correct folding and function of the MHC class II complex. To function correctly, Ii must form a trimer, and the TM domain is one of the domains thought to stabilize the trimeric state. Specific mutations in the TM domain have been shown previously to disrupt MHC...

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Share to Antigens, Differentiation, B-Lymphocyte
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Histocompatibility Antigens Class II

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Identifiers

PMID: 16618111
DOI: 10.1021/bi052112e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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