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Article

Shared genetic risk between major orofacial cleft phenotypes in an African population.

Genetic epidemiology - 1 Sept 2024

Alade Azeez, Peter Tabitha, Busch Tamara, Awotoye Waheed, Anand Deepti, Abimbola Oladayo, Aladenika Emmanuel, Olujitan Mojisola, Rysavy Oscar, Nguyen Phuong Fawng, Naicker Thirona, Mossey Peter A, Gowans Lord J J, Eshete Mekonen A, Adeyemo Wasiu L, Zeng Erliang, Van Otterloo Eric, O'Rorke Michael, Adeyemo Adebowale, Murray Jeffrey C, Lachke Salil A, Romitti Paul A, Butali Azeez

Abstract excerpt

Nonsyndromic orofacial clefts (NSOFCs) represent a large proportion (70%-80%) of all OFCs. They can be broadly categorized into nonsyndromic cleft lip with or without cleft palate (NSCL/P) and nonsyndromic cleft palate only (NSCPO). Although NSCL/P and NSCPO are considered etiologically distinct, recent evidence suggests the presence of shared genetic risks. Thus, we investigated the genetic overlap between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38634654
DOI: 10.1002/gepi.22564

Genes

ARCN1
KMT2A
MDN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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