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Article

High Free Cholesterol Bioavailability Drives the Tissue Pathologies in Scarb1-/- Mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2021

Liu Jing, Gillard Baiba K, Yelamanchili Dedipya, Gotto Antonio M, Rosales Corina, Pownall Henry J

Abstract excerpt

Objective: Overall and atherosclerosis-associated mortality is elevated in humans with very high HDL (high-density lipoprotein) cholesterol concentrations. Mice with a deficiency of the HDL receptor, Scarb1 (scavenger receptor class B type 1), are a robust model of this phenotype and exhibit several additional pathologies. We hypothesized that the previously reported high plasma concentration of free cholesterol...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34380332
DOI: 10.1161/ATVBAHA.121.316535
PMCID: PMC8458258

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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