Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sequencing and functional characterization of SCARB1 variants in subjects with extreme HDL cholesterol levels.

Journal of clinical lipidology - 1 Feb 2026

Gracia-Rubio Irene, Benito-Vicente Asier, Lamiquiz-Moneo Itziar, Bea Ana María, Marco-Benedí Victoria, Cabrera-Antón Endika, Martín César, Civeira Fernando, Cenarro Ana

Abstract excerpt

BACKGROUND: Rare variants in SCARB1, which encodes the high-density lipoprotein (HDL) receptor scavenger receptor class B type 1 (SR-B1), are hypothesized to drive unexplained extreme levels of plasma HDL cholesterol (HDL-C). OBJECTIVE: We sequenced and phenotypically correlated SCARB1 by analyzing individuals with extreme HDL-C levels and characterizing the functional consequences of rare identified variants....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholesterol, HDL
Share to SCARB1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to HEK293 Cells

Share to Scavenger Receptors, Class B

Source

Identifiers

PMID: 41486059
DOI: 10.1016/j.jacl.2025.11.017

Genes

SCARB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequencing and functional characterization of SCARB1 variants in subjects with extreme HDL cholesterol levels.PMID 41486059Read ↗

Impact of genetic variants in human scavenger receptor class B type I (SCARB1) on plasma lipid traits.Semantic proximity Read ↗

SCARB1 Gene Variants Are Associated With the Phenotype of Combined High High-Density Lipoprotein Cholesterol and High Lipoprotein (a).Semantic proximity Read ↗

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease.Semantic proximity Read ↗

Genetic contribution of SCARB1 variants to lipid traits in African Blacks: a candidate gene association study.Semantic proximity Read ↗

Association of the Lipoprotein Receptor SCARB1 Common Missense Variant rs4238001 with Incident Coronary Heart Disease.Semantic proximity Read ↗

Rare SCARB1 mutations associate with high-density lipoprotein cholesterol but not with coronary artery disease.Semantic proximity Read ↗

Variants in scavenger receptor class B type I gene are associated with HDL cholesterol levels in younger women.Semantic proximity Read ↗

Targeted next-generation sequencing to diagnose disorders of HDL cholesterol.Semantic proximity Read ↗

A coding variant in SR-BI (I179N) significantly increases atherosclerosis in mice.Semantic proximity Read ↗

Exome wide association study for blood lipids in 1,158,017 individuals from diverse populationsSemantic proximity Read ↗

Identification of four novel genes contributing to familial elevated plasma HDL cholesterol in humans.Semantic proximity Read ↗

Influence of SCARB1 gene SNPs on serum lipid levels and susceptibility to coronary heart disease and cerebral infarction in a Chinese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.